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Genetics
69 cards·by Simiankolya
Allopolyploid
Polyploid by hybridization between two difference species
Autopolyploid
An organism with more than two sets of homologous chromosomes
Aneuploid
A cell in which the chromosome number is not an exact multiple of the haploid number
Balanced translocation
In which non-homologous chromosomes interchange but all parts are present
Barr body
During interphase, in the nucleus of a female mammal cell - the result of an inactivated X
chromosome
Conjugation
Cell to cell transfer of DNA between bacteria, via a pilus or conjugation bridge
Deletion/Deficiency
The loss of a segment of genetic material from a chromosome
Dosage compensation
The inactivation of an X chromosome in a female mammal, which results in a single active X that
affects females to the same degree as males
Duplication
In which a chromosome segment is present more than once in a haploid genome
Euploid
In which the chromosome number is equal to the haploid number
F factor
A segment of plasmid DNA that transfers from one bacterium to a bacterium lacking the plasmid,
allows conjugation
F' plasmid
The adjacent bacterial DNA that is carried with the F factor into the F- cell
Genetic mosaic
An organism composed of two or more genetic types of cells
Hfr cell
E. coli cell with F factor incorporated into its genome
Heterochromatin
A chromosome that remains condensed/stained during interphase
Pericentric inversion
Several genes with their order reversed; including centromere
Paracentric inversion
Several genes with their order reversed; not including the centromere
Prototroph
A microbe that can grow in minimal medium with only a carbon source and inorganic compounds
Replication slippage
A small number of tandem repeats that can increase or decrease
Tandem duplication
A pair of identical or related DNA sequences that are adjacent and in the same orientation
Transduction
The carrying of information from one bacterium to another via a bacteriophage
Transformation
In which whole plasmids enter a cell as naked DNA
Translocation
The interchange of parts between non-homologous chromosomes
Triploid
A cell having three complete sets of chromosomes
Trinucleotide repeats
A tandem series of three repeating base pairs
Trisomic
A cell having three copies of a chromosome
Uniparental inheritance
Inherited from only one parent, i.e. Y chromosome
Conditional mutant
A mutation that results in a mutant phenotype in restrictive conditions, but a wildtype in
permissive conditions
Replica plating
Template made from cell colonies on agar; colony cells transferred to cloth
Alternative splicing
Different ways for epigenetics to splice genome
Basal transcription factor
Recruits RNA polymerase
cAMP-CRP
In the absence of glucose, recruits RNA polymerase & speeds up Lac ZYA production.
Constitutive expression
Always turned on
Enhancer
Cis element close to or adjacent to the gene acted on. Binding site for activator.
Fitness
Liklihood of producing fertile offspring (w = 1-s; s = selection coefficient).
Floral organs
Sepal, Petal, Stamen, Carpel
Forward mutation
Change from wild type to mutant allele
Founder effect
Small population isolated, most likely to lose rare alleles due to oversampling.
Frameshift mutation
Caused by insertion/deletion.
Gain-of-function
Gene over-expressed or inappropriately expressed
Gene pool
All genes in a population
Genetic drift
Slow change of a gene pool by random chance
Genotype frequency
p^2 + 2pq + q^2
Heterochromatin
Condensed silenced chromatin
Heterozygote advantage
Sickle cell anemia, for example
Imprinting
The process by which epigenetic imprints are passed down from a parent
Insulator
Separates individual genes from each other
Intercalating agent
Inserts like a base pair but does nothing; causes deletions & frameshift mutations
Merodiploid
Diploid for for allele in bacterium due to the presence of a plasmid
Missense mutation
A mutation that causes the wrong amino acid to be coded for
Neutral mutation
A silent mutation
Nonsense mutation
A mutation that produces a stop codon in the wrong place.
Operator
Binding site for repressors, "light switch"
Phenotype frequency
Ratio of a phenotype in a population
Promoter
Site for initial binding of RNA polymerase
Repressor
Binds to operator, switches gene "off"
Reversion
A mutation that undoes a previous mutation, back to the wild type
Silencer
A cis site where the repressor binds
Silent mutation
A mutation that doesn't change which amino acid is coded for
Neutral mutation
A silent mutation
Spliceosome
An enzyme that splices stuff at splice site, and splices out introns
TATA box
Location on promoter where RNA polymerase attaches
Thymine dimers
Chemical bonds that form between adjacent thymines; causes kink in DNA but fixed by cellular
repair mechanisms
Translation
RNA -> amino acids; in ribosome
Constitutive
I+ P O+ Z- / I+ P O- Z+
Inducible
I+ P O- Z- / I+ P O+ Z+
Constitutive
IS P O+ Z+ / I+ P O+ Z+
Uninducible
IS P O- Z- / I+ P O+ Z+
Inducible
IC P O- Z- / I+ P O+ Z+