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PHOL2005
mecp2
pro binds to methylated cytosines
neuregulin
encode cell adhesion pro at synapse
neuregulin
ex/ inh ratio
FRM1
pro regulated proteins at synapse
disc1
intra cell scaffold
disc1
developmentaly regulated
GSK3-beta
regulate synapse structre and function
alpha-synmilein
presynaptic pro
alpha-synmilein
prominent in lewy bodies
ATP/adenosine
release BSNF
evironmental signal
promote growth cone formation
evironmental signal
control behaviour of growth cone and axon growth
1
mylein brack down
mylein breakdown
express MAG/OMG inh regrowth
2
expression of molecuels that promote axon growth
3
regen tracts
regen tracts
bands of bungner
regen tracts
guide axon to target
astro
exhibit inh moleules, enlarge and proliferate
method 3
increase regen capacity
increase regen capacity
elevated camp levels
TSC1/2
tuberous sclerosis
tsc1/2
intracell signalling
neuregulin 3/4
cell adhesion
neuregulin 3/4
ratio of ex/inh
new da drugs
5ht2a
alpha synmilein
presynaptic
alpha synmilein
missence mutation A53T and A30D
parkin
sbs ldc rel-1
parkin
regulates synaptic vesicle release