PDA: Drugs for Pain

Pain drug names and their functions, mechanisms and side effects

9 cards·by lizzieheinonen

drug actionpharmacologymedicinepaindrugs

Amitriptyline (Elavil)

blocks Na+ ion channels of the peripheral nerves, inhibits serotonin-norepinephrinere-uptake. SE: dizziness, headaches, weight gain

Aspirin

inhibits COX enzymes (cycoloxygenases, COX1) or PTGS 2, suppresses production ofpro-inflammatory mediators, SE: GI bleeding, tinnitus

Carbamezapine

blocks NA+ channels, primary in treatment of epilepsy and neuropathic pain, SE: drowsiness, dizziness, headaches & migraines,

Gabapentin

blocks CA2+ channels of peripheral nerves, modulates action of GAD (glutamate decarboxylase) and BCAT. SE: dizziness, fatigue, ataxia

NSAIDs

competitive inhibition of COX enzymes SE: increases risk of GI problems, nausea/vomiting, dyspepsia, gastric ulceration/bleeding, diarrhoea

Codeine

weak opiod, treats mild to moderate pain & to relieve cough, diarrhoea. SE: addiction, suppression of breathing, diarrhoea, nausea

Tremadol

weak opiod, treats moderate to moderately severe pain. SE: addiction, suppression of breathing, diarrhoea and nausea

Morphine

strong opiod, treats both acute and chronic pain, frequently used for MI pain and labour pain. SE: addiction, suppression of breathing etc

Fentanyl

strong opiod, potent drug with rapid onset & short duration of action (50-100x morphine). SE: addiction, suppression of breathing, diarrhoea